Sunday, September 16, 2018

The Biology behind Type 2 Diabetes insulin resistance or adult onset diabetes


Adult onset Type 2 Diabetes, Insulin Resistance

In 1955, when I was born, about the same time that the first Bariatric Surgeons and Gastro intestinal surgeons were making ground breaking discoveries into the root cause of Type 2 Diabetes.  Because a new Surgical procedure had been invented known as the duodenal bypass (or Gastric Bypass) which was used to treat duodenal ulcers, intestinal cancers and obesity.   But an unexpected side effect was occurring; when this surgical procedure was done on Type 2 Diabetics it instantly cured them of Type 2 Diabetes.

These Bariatric Surgeons and Gastro Intestinal Surgeons published their findings in their respective journals, but unfortunately the official Diabetic experts, the endocrinologists, didn’t spend much time reading those journals, because they had their own Endocrinology journals to read.  So, this discovery went unnoticed for decades by the top Diabetic experts.  These 2 groups of medical professions rarely had anything to do with each other until 1993.

Endocrinologist means Internal Hormone doctor.  Because Diabetes is an internal Hormone malfunction, with Insulin Hormone malfunction being the primary focus of this disease.   But this disease really effects about every hormone in your body eventually.  Insulin is just one digestive hormones amongst many that are also involved.

My Grandfather died of Type 2 Diabetic Hyperglycemia (High Blood Sugars) at the age of 66 after eating a Thanksgiving Dinner in 1966, he was of a normal weight, but had suffered from heart disease for many years.  It was very common for him to have a heart attack every other day, and be bed ridden for the rest of the day with an oxygen mask and nitroglycerin pills.  All caused by his Type 2 Diabetes (Insulin Resistance).  He was taking many kinds of medications as well as insulin.

My Father Had Type 2 Diabetes and died in the year 2000 of kidney failure caused by Diabetes at the age of 70.  All my Aunts (all normal weight) on my Father’s side of the Family all had Type 2 Diabetes as well, but most lived much longer, one even lived to be 95 years old.  My Father was overweight, and he also drank beer with his metformin, which destroyed his kidneys.  Many diabetics lose their kidneys this way.

Metformin primarily fights insulin resistance, not stimulate insulin production.  A Type 2 Diabetic can produce as much as 32 times more insulin than a none diabetic, but over time the pancreas will be damaged to the point you may eventually need insulin injections as the pancreases gradually fails if the Type 2 Diabetes isn’t well managed or controlled.  But most Type 2 Diabetics rarely need insulin, usually diet and medications are all that is needed.   So, as you can see, Type 2 Diabetes is clearly more to do with insulin resistance, than insulin production most of the time.

The Side effects of Metformin (or Glucophage) include diarrhea, stress on the kidneys, stress on the heart and other organs.  Especially the kidneys if the Diabetic patient drinks too much alcoholic beverages.   When Alcohol mixes with Metformin it creates and acid that can destroy your kidneys.  So, anyone taking Metformin should stay away from all alcoholic beverages.

At one point in history Metformin was taken off the market because it was destroying people’s kidneys, but once it was understood that the destruction was more to do with mixing this medication with alcohol, then it returned to the market, with the stipulation that the Type 2 Diabetic had to stay away from alcohol. 

MY EXPERIENCE OF TYPE 2 DIABETES

Even though I did not know what the symptoms of diabetes were at that time, my first symptoms of Diabetes that I recalled was when I was a Teenager, I started to get Dandruff really bad, ACNE that was so horrible that it looked like my skin went through the meat grinder a couple of times, constant psoriasis of the skin in places where the sun never shined (including Dandruff), jock itch, heat rashes in my groin area, a numbness in my Thys, numbness in my fingertips,  constantly sleepy and tired in the middle of the day, getting sleepy right after eating, taking long naps in the afternoon and missing out on daily activities that my friends were out doing.  While pissing like a race horse frequently.

Even though I was very athletically involved in football, ping pong, track and field, I would quite often go home very tired and sore, and the next morning feel like I got ran over by a MAC truck a couple of times.  I only weighed in at 140lbs, but I was also 6 ft 1 inch tall, a normal weight should have been 160lbs, So I was 20 pounds underweight, but still suffering from symptoms of Diabetes.

As I got older and gained more weight, these symptoms got worse, I didn’t get diagnosed with Type 2 Diabetes until I was 38 years old and weighing about 250lbs, after suffering from impotence problems.   Another symptom of Type 2 Diabetes is premature menopause, in men it is called Andropause.  As you gain weight the symptoms of diabetes get progressively worse.

I officially had Type 2 Diabetes for 16 years after being diagnosed, before I had it surgically removed in 2012 with a Duodenal Switch operation.  But before I did that, I had been on 2 different types of Insulins using maximum doses, Metformin (insulin anti-resistance drug), 3 Different blood pressure medications, 3 different cholesterol medications and 120 units of Methotrexate injections twice a day for my psoriasis and rheumatoid arthritis.

Keep in mind that the country with the highest percentage of Diabetics is India, even though 67% of them are vegetarians, 9% of their population are diabetics, compared to America where 8% are officially diagnosed with diabetes.  Also remember that a clear majority of Indians are very thin.  When was the last time you saw a fat Indian (living in the country of India, Not Native Americans)?  Indians are some of the thinnest people in the world, so clearly being fat is not the underlining common denominator for Diabetes.

2/3rds of the Diabetic population are either normal weight or thin.  1/3rd are overweight and less than 1% are obese, at least obese enough to qualify for Gastric Bypass surgery (BMI > 35).

TYPE 2 DIABETIC HISTORY

In 1993 an Italian Doctor by the name of Dr. Francesco Rubino had a Diabetic Patient with a BMI of 83 and was reading through the medical journals to find the best treatment for his diabetic patient and kept running into those Bariatric and Gastro Intestinal journals going as far back as the 1950’s, that were mentioned earlier, talking about how Type 2 Diabetes was Getting eradicated through a duodenal bypass surgery.   So, Dr. Rubino went to the medical labs using diabetic rats and repeated those surgeries on diabetic rats.

The results were confirmed, that when Dr. Rubino bypassed the Duodenum Type 2 Diabetes went away in the diabetic rats, and when he restored the Duodenum back to its original function; the Type 2 Diabetes returned.  He was able to confirm that it wasn’t even the entire duodenum at fault, it was only the first half of the duodenum that was the source of Type 2 Diabetes. 

Dr. Rubino repeated the same experiments on thin diabetic rats and got the same exact results.   So, he effectively proven that Type 2 Diabetes was a disease of the upper intestine, and not caused by being fat.  Fat only makes the disease worse but is not the real root cause of Type 2 Diabetes.  The duodenum is the first 12 inches of the small intestines in humans.  It sort of looks like a second stomach attached to your main stomach as it bulges out like a second stomach, then wraps around and connects to the jejunum, but it is part of the Small intestine.  The small intestine has 3 different sections, the Duodenum, the Jejunum and the Ileum.   Type 2 Diabetes is strictly a function of the Duodenum itself.

The Biology behind Type 2 Diabetes

The biology of the Duodenum is complicated, but to simply what appears to be going on, is that the duodenum is designed to absorb Iron, as each section of your intestine specializes in the absorption of specific nutrients from your food, some sections absorb Vitamin A, others Vitamin C and near the end Vitamin B & Proteins for example.

When the Duodenum malfunctions it may absorb proteins (which is the wrong part of the intestine to be absorbing proteins) incorrectly, and those proteins get mistaken for digestive hormones like Insulin, Glucagon, Amylin, Ghrelin, etc., …. And end up corrupting those hormone receptors.  If they corrupt the Insulin receptors, you get Type 2 Diabetes insulin resistance.  If they corrupt Amylin receptors you get Amylin resistance and gain weight, if it corrupts Glucagon receptors your liver may not make glucose (sugar) when your body needs it, which will result in low blood sugar attacks and very difficult to lose weight, etc., …

In Type 2 Diabetes the insulin resistance means your cells are not eating the Sugar because they can’t find the sugar in your blood stream.  The Insulin hormone simply communicates a hormonal message between a sugar molecule and a cell, permitting the cells to find the sugar in your blood.  It is the cells eating the sugar that actual lowers your blood sugar, not the insulin itself.  But this doesn’t work well if the insulin receptors are corrupted with duodenum proteins that interfere with these communications.

The cells then take that freshly eaten sugar to the Cells Mitochondria to bond with oxygen to create energy with the help of an enzyme, this causes your Mitochondria to chemically vibrate and keep your cells alive.  It is that vibrating Mitochondria that is the heart beat of your cells that keeps your cells alive and functioning.

If that sugar molecule contains a vitamin or nutrient of some sort, that vitamin or nutrient converts that energy into literal work in that cell.   Most sugar molecules from natural sources like fruits and vegetables contain high levels of vitamins and nutrients of different kinds.  It is refined sugar that does not contain anything useful for producing work in each cell.   So, it isn’t just about keeping the Mitochondria vibrating, but is also about getting some work done in the cell itself, so that each cell can function and perform valuable work for your body.

MY EXPERIENCE WITH GETTING MY DIABETES SURGICALLY REMOVED

I entered the Hospital on April 23rd,2012, I could barely walk 100ft without having to stop to get my breath back.  And suffering from a Low Blood Sugar Attack.  I was taking 2 different kinds of insulin 120units of Basal Insulin twice a day and regular meal insulin 3 times a day, Metformin, 3 different Blood pressure medications, 3 different anti-cholesterol medications, heart medications, Nitroglycerin for my heart disease, massive amounts of Methotrexate for my psoriasis and CPAP machine for my Sleep Apnea.  My pharmacist was making a really good living off of me.

I had the duodenal switch operation which has the greatest success for weight loss and curing type 2 diabetes (a 98% success rate), I was already weighing in at 380lbs.  In the duodenal switch operation both the Duodenum and Jejunum are bypassed, and the Ileum replaces the digestive path of those other 2 sections.   Remember that the small intestine is about 30 feet long, and the Duodenum is only 1/30th of that 30 feet, which is 12 inches as previously mentioned.  Most of that 30 feet is the Jejunum; the Ileum is about 2 to 4 meters (or 6ft to 12ft long) at the end of the small intestines.

Right after surgery, all my hunger pains were gone.  And the Low Blood sugar attack I was suffering from right before the surgery was gone, and never happened again.

SIDE EFFECTS OF THE DUODENAL SWITCH OPERATION:

3 Days after the surgery my Diabetes was cured, I wasn’t taking anything, no more insulin, no more Metformin, no more Blood pressure medications, no more Anti-cholesterol medications and no more methotrexate.  However, When I left the Hospital 5 days after surgery I did leave the hospital wearing about 5 colonoscopy bags, because I started losing so much weight on the 4th day so fast that water was exiting my fat cells so quickly that water was squirting out of my surgical incisions and stitches. 

SUPER FAST WEIGHT LOSS:

I looked like a water fountain or one of those cartoons where when they get shot up, Bugs Bunny drinks a glass of water, then water squirts out of his body like a water fountain.  However, the numbness in my thighs disappeared, the dumbness in my fingertips disappeared, my Sleep Apnea went away.  I wasn’t peeing like a race horse every 30 minutes like I used to.  My dandruff went away, my skin psoriasis went away.  My skin started to take on a younger moister texture.  And the squirting and leaking water went away about 2 weeks after the surgery.

EFFECTS ON MY MOTABOLISM:

I was also finding it very difficult to sleep, it seemed like every cell in my body was now running on nuclear power.  I never felt tired or sleep like I used to, not even at night when I was supposed to sleep.  But over about 6 months’ time my normal sleep cycles returned, but even then, I was only sleeping about 4 to 6 hours instead of 8 hours.  I guess 8 hours of sleep is intended for diabetics.

1 month after surgery I took a sleep apnea test and was found to be cured of sleep apnea.

3 months after surgery; my doctor did a sonogram of my heart and found that the hardening of my arteries had completely cleared up.  I also went to see my cardiologist and he confirmed the same thing and that I no longer needed nitroglycerin or other heart medications either.  By this time my weight had dropped all the way down to 220 lbs, a total weight loss of 160 lbs in 3 months, most of it lost in the first 3 weeks after the operation. 

My Cardiologist says his other patience that got the same procedure experienced the same exact things that I went through.  A completely clearing up of the hardening of my arteries, like it was some sort of sinuous cleansing.

When I worked out, I could run a full lap or 2 at full speed and not even find myself breathing hard.  And when I woke up in the mornings, I wasn’t sore or tender everywhere like I used to be.  I was in better shape now at age 56 than I was when I was a teenager playing interscholastic league football.

MENAPAUSE:

When this procedure is done on women, and they suffer from premature menopause caused by Type 2 Diabetes, their Menopause is reversed, and they will immediately start to have perfectly synchronous 28-day menstrual cycles, even if they never had perfect 28-day menstrual cycles before and be able to conceive starting about 18 months after surgery.  While getting their sex life and child bearing years fully restored.

However, men that get Andropause because of Type 2 Diabetes do not get their sex life back from this procedure.  Andropause is a permanent condition.  So, if you have Type 2 Diabetes and haven’t gotten Andropause yet, you should seriously consider this procedure before you do get Andropause.  Otherwise you sex life will be permanently lost.

THE COSTS FOR THIS PROCEDURE:

This surgery only cost $8,000 to $25,000 plus hospital stay, which is probably a bargain considering that in previous years I was in the hospital once or twice a year from diabetic complications that cost hundreds of thousands of dollars each time.

You will also be required to go through 6 months of medical and psychological examinations, including biopsy of your digestive track to confirm you are not a Type 1 Diabetic but instead a full blown Type 2 Diabetic and your Duodenum is causing it.  Before you get the actual surgery.

It is now 6 years later, and I am still cured of Type 2 diabetes….  And haven’t needed a hospital stay again do to Diabetic complications.

BETTER NEWS:

Good news is that Doctor’s in Chili have recently invented another technique that is far less intrusive in addition to costing many orders of magnitude less, and it is called the Endobarrier.   This is where they insert a capsule on a string and into your stomach and duodenum then blow up an inflatable cylinder into the Duodenum, that latches onto the inside of your stomach.  Thus, covering up the Duodenum completely as it inserts itself into the duodenum while inflating.  This is said to be just as effective as the Duodenal bypass (Gastric Bypass), for so long as food does not touch the Duodenum, Type 2 Diabetes is eradicated.

There are now intense studies being done in universities around the world developing drugs and procedures to fix the duodenum itself.  The ideal cure would be a drug that fixes the duodenum.  It might even be possible that a natural plant, fruit or vegetable might fix the duodenum and avoid any of these complicated and risky procedures.

By Edmund Williams

Sources:


American Diabetes Association Publication dated 09/23/2014
My own personal experiences
12 years of Diabetic education by Endocrinologist dietitians.  (Standard procedures by endocrinologist)
Forest Park Medical Center & Barker Bariatrics



Friday, September 14, 2018

Health and Fitness for all

Learn some of the inside secrets of Health and Fitness when it comes to loosing weight and managing your Diabetes.

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Also download the free books and information on Health and Fitness Guide.

Thanks,

    Edmund